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In fact, the overexpression of mitochondrial GPx4, but not nonmitochondrial GPx4, suppressed mitochondrial oxidative stress (36) and apoptosis mediated by the mitochondrial pathway in rat basophile leukemia cells (RBL2H3 cells) (37), suggesting that nonmitochondrial GPx4 plays a limited role in mitochondria (38)

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Recently, we have shown that purine metabolites were also linked to neurological and cognitive symptoms in the FENNS patients (Yao et al., 2012)

They represent roughly 36, 18, and 18 percent, respectively, of the total carotenoid content of the retina

L-carnitine supplements can increase the amount of carnitine in the blood and inside cells, which can help prevent many of the symptoms of carnitine deficiency