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Description

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Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically

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SIRT1 is widely expressed in normal renal tubular cells and podocytes, but decreases with renal diseases or ageing (Lim et al., 2012)

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