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F.GratasC.et al

Kaplon, J

While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

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For example, HMGB1, a DAMP that triggers the inflammasome and promotes the release of pro-inflammatory cytokines including IL-1 and IL-18, can be released by ferroptotic neutrophils