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Clearance is the most important pharmacokinetic term to be considered in defining a rational steady-state drug dosage regimen

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DTNB reacts not only with thiocholine, but also with thiol groups in the blood and the reaction between DTNB and thiol groups is completed within 10 min 28

Furthermore, a recent mouse study showed that physiological ROS levels in astrocytes are needed to regulate metabolic rewiring, which modulates the PPP flux with potential implications on neuronal survival and cognitive impairment