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Human CBS was cloned into pcDNA5-FRT encoding for a C-terminal Flag-mKO2-tag for the mammalian expression vectors

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49 On the contrary, high iron content in cells will reduce iron intake and increase iron storage by releasing of IRP1/2 from IRE of TfR1 and ferritin

Furthermore, according to this study, Set7/9 was shown to act, in contrast to PGC-1, as a positive regulator of NFkB, hence activating the NFkB-dependent pro-inflammatory gene expression program