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Seizures can precede the cognitive decline in Alzheimers, and definitely contribute to it, Wang says

LH/FSH dysregulation an elevated LH-to-FSH ratio produced by abnormally rapid GnRH pulse frequency in the hypothalamus, creating a hormonal environment that stimulates androgen production while suppressing follicle maturation.[3] Chronic low-grade inflammation elevated CRP, IL-6, and TNF-, even in lean women with PCOS and in the absence of obesity, suggesting that inflammation is a core feature, not a secondary consequence of excess weight

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These outcomes align with the local effect theory

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