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In its 2023 research roadmap, the Lipedema Foundation highlighted the lack of validated, clearly druggable targets as a critical unmet need and called for urgent scientific action [8]

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Another animal experimental study discovered that chronic treatment with berberine significantly and dose-dependently decreased levels of oxidative stress markers (MDA, GSH), thereby ameliorating cognitive deficits and cholinergic dysfunction in diabetic rats (58)

2a, b), although they were decreased in frequency and numbers (Supplementary Fig