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Nature 520 , 5762 (2015)

Progesterone receptor membrane component 1 inhibits the activity of drug-metabolizing cytochromes P450 and binds to cytochrome P450 reductase

In summary, variant effect maps based on experimental measurements of the growth of yeast cells expressing human CBS gene variants, without any further computational fitting or calibration based on human traits, yielded diploid scores that strongly correlated with clinical phenotypes in patients with classical homocystinuria