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Fourth, reverse causality remains a fundamental concernit is unclear whether dysbiosis precedes and promotes comorbidity, or whether the physiological consequences of constipation and depression (reduced motility, altered diet, medication use, stress) drive observed microbiota changes

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As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run.[28] Figure:2 ROLE OF GLUTATHIONE IN SKIN DISORDERS OTHER THAN HYPERPIGMENTATION : A decrease in the cellular and serum levels of glutathione has been speculated to be associated with the pathogenesis of autoimmune and inflammatory dermatoses that include psoriasis, vitiligo, alopecia areata, polymorphic light eruption, acne vulgaris, etc

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