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In 2020, the results of a clinical trial were published in the New England Journal of Medicine that demonstrated the effectiveness of semaglutide for weight loss

J Neurosci 13:20132023 Johnson JA, Johnson DA, Kraft AD, Calkins MJ, Jakel RJ, Vargas MR, Chen PC (2008) The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

Higher Nrf2 binds to the cis -region of antioxidant responsive element (ARE)

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