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These tissues are key contributors to metabolic health, and examining their responses could provide important insights into the systemic effects of CR and fasting in AD mice

10.1371/journal.pone.0056306 69 LuoY.YuY.ZhangM.HeH.FanN

Trials with high-risk patients may be restricted due to ethics for treatments that are known or expected to be effective, and they increase difficulty for recruiting