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Recently, Ji et al

At its core: a two-step enzymatic cascade

this phenomenon causes mitochondrial dysfunction with increased superoxide radical levels at peak pain, triggering signaling cascades that may underlie the coasting effect, such as apoptosis

Cancers (Basel) 12, (2020), Application(s): WB, Abstract Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain: Aggarwal, S., DeBerry, J