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Additionally, the review provides a research roadmap by developing three testable hypotheses: (i) ROS levels are directly correlated with thrombotic events in COVID-19, (ii) OxLDL levels are increased in hypercholesterolemic patients with severe disease outcomes, and (iii) redox balance restoration reduces vWF release and NET-mediated thrombosis

qRT-PCR analysis Raw 264.7 cells were seeded in a 6-well plate (3 10 5 cells per well) and stimulated with LPS (10 g/mL) for 24 h

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However, many of these models were established using small animals, such as mice, rats and rabbits, which involve different characteristics from the human spine, particularly in terms of disc anatomy and mechanical loading of vertebrae