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Given the potential of reduced gliotoxin to thiolate cellular proteins, we speculate that reduced gliotoxin may be sequestered into intracellular vesicles where it is converted to the oxidized form, by an unidentified activity, prior to release from the cell by an exocytotic mechanism complementary to GliA-mediated efflux (Figure 7)

10.1186/s13020-022-00571-1 130 PayneA.NahashonS.TakaE.AdinewG

Cholesterol-induced metabolic reprogramming in breast cancer cells is mediated via the err pathway

By targeting the mitochondria the powerhouses of cells it helps improve energy production, stamina, and recovery in horses and livestock

This study provides an illustration of some of the key points of polymer therapeutics from the laboratory to the clinic