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This structural damage further impairs ATP production, leading to the hallmark symptom of ME/CFS: post-exertional malaise (PEM), a severe exacerbation of symptoms following even minor physical or cognitive exertion

It contains sulfur, which helps break down thick mucus in the respiratory system

Pseudo-colored green areas indicated mitochondria (blue fluorescence, left), and pseudo-colored red areas indicate mitochondrial H 2 O 2 (yellow fluorescence, middle)

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This leads to cytosolic mtDNA accumulation, which activates the cGASSTING pathway, driving proinflammatory cytokine production