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People deficient in vitamin B12 may only experience some of these symptoms or a few in combination

These may need to be surgically removed if they become problematic

The upregulated CD38 was also observed during the aging process, by secreted cytokines IL-6, interferons and soluble factors from senescent cells as part of so-called senescence-associated secretory phenotype (SASP) 21,27,36,47,48,49,50