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PLoS One 11(11):e0165704

In -cells, GLUT2-mediated glucose entry elevates, via oxidative metabolism, the intracellular ATP level, which in turn leads to K ATP channel inhibition (Ashcroft et al., 1984

G6PD deficiency (G6PD-d) is the most common enzymopathy in the world, with approximately 500 million affected people worldwide

Indeed, under HFD, GSH depletion also significantly decreased expression of Ccl2 and Tnfa (TNF-), cytokines that promote inflammation and immune cell recruitment (Figure 3B)