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HSL translocates from the cytosol to LDs (42) in response to hormonal stimulation which requires PLIN1 (15) through direct interaction (43, 44) (Figure 1)

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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)