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Acknowledgements The authors are grateful for the collaboration of the National Institute of Oceanography and Fisheries (NIOF), Egypt and Benha University

A pivotal role of ageing in triggering neurodegenerative disease critically involving lysosomal mechanisms is consistent with genes that cause a congenital devastating lysosomal storage disorder (LSD) when homozygously mutated, but are also major risk factors for a late age-onset neurodegenerative disorder, such as PD (for example, GB1 ) or frontotemporal dementia (FTD) (for example, GRN ), when only one mutant copy is inherited 39,40