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Piriformis Syndrome: The piriformis muscle, located deep in the buttock, spasms or tightens and irritates the sciatic nerve, which runs right beneath or sometimes through it

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The B12 component adds a separate cardiovascular benefit

Approximately 11.9-fold increase in endogenous MOTS-c levels have been found in skeletal muscle following exercise (compared to pre-exercise values), and this increase can remain for 4 hours following exercise (19)