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10.1016/j.nantod.2024.102368 112 SiegelR

In vivo, overexpression of iNOS and the accumulation of 8-OHdG, critical biomarkers of oxidative stress, were found in NPC patients

Furthermore, adding sodium bicarbonate to buffer local anesthetic solutions like lidocaine and bupivacaine can reduce injection pain by increasing pH, enhancing anesthetic effectiveness