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Hum Mol Genet 14: 22012208

As with other GLP-1 agonists, the medication helps regulate blood sugar levels by triggering insulin release and limiting the release of glucagon

This faster renewal process sheds the top layer of skin that contains the excess pigment, reducing the appearance of dark spots over time

It also prevents the migration and adhesion of RPE cells involved in the formation of epiretinal membranes in AMD, through inhibition of PDGF-beta receptor activity and downstream signaling pathways [90]

In vitro studies provide further mechanistic insight, showing that lithium enhances mitochondrial function, supports oxidative balance, and prevents apoptosis through mechanisms involving cytochrome c regulation, Bcl-2 modulation, and preservation of complex I activity