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It was also reported that microglia are capable of removing incorrectly deposited myelin directly from the axon, contributing to the refinement of myelin sheaths, as shown in zebrafish and mice during development (Hughes and Appel, 2020

Effects of cadmium on structure and enzymatic activity of cu,ZnSOD and oxidative status in neural cells

This "split-dosing" strategy can help maintain more consistent levels in the bloodstream throughout the entire 24-hour cycle

Unlike existing reviews that primarily discuss PROTAC biology, degrader chemistry, or delivery systems in a more general manner, this review focuses specifically on the chemistry-guided design logic of smart delivery systems for PROTACs and on how the unique structural and physicochemical features of PROTACs impose distinct delivery requirements