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These miRNAs and especially miR-223 which are involved in PI3K/AKT, IGF1, and MEK/ERK/NF-B signaling cascades could represent a molecular link between inflammation and cancer

PMC pub Health, 2012 12:394 Andrs, E., Serraj, K., Zhu, J., & Vermorken, A

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Therefore, there have been suggestions that GAC needs to form a higher-order oligomeric state in cells, resulting in a filament-like structure, in order for catalysis to occur [22, 24, 29]