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For instance, dual pH- and redox-responsive polymeric and micellar carriers have been optimized for curcumin, exhibiting controlled degradation and sustained intracellular release in tumor microenvironments (Pillarisetti et al., 2017)

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Several development programmes for the treatment of excessive daytime sleepiness [155, 156], orthostatic hypotension [157], and cognitive impairment [158, 159] were discontinued