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Measey, 2021)

2002: Leyden et al

Contraindicated / avoid: personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) based on a rodent thyroid C-cell tumor signal and known hypersensitivity to the drug

However, the regulatory framework for drug development relies heavily on animal toxicology precisely because it does provide meaningful safety signals