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Elevated B12 levels likely enhanced oocyte maturation and embryo viability through improved methylation capacity [7], as evidenced by the positive correlation between B12 levels and embryo morphology in our cohort (Table 2)

Semaglutide works by binding the GLP-1 receptor in pancreatic beta cells and hypothalamic appetite centers, where it enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces hunger signals

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Administered in sequence rather than simultaneously, this protocol targets both mitochondrial efficiency and enzymatic regulation of fat storage, with typical research cycles running 812 weeks