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In addition, the alteration of GAPDH and PK in AD was further described by an immunoproteomic approach that demonstrated the presence in the CSF of autoantibodies against these enzymes (397), consistent with the notion that proteins undergoing ox-PTMs become toxic to neurons, which induce clearance systems and immune responses

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Encapsulation of DDA-GSH-AuNCs into PLGA nanoparticles using the emulsion-evaporation method PLGA (30 mg) was dissolved in chloroform containing DDA-GSH-AuNCs (1.5 mL), and then emulsified into aqueous PVA solution (2.5% w/w, 5.0 mL) using sonication for 60 s (ultra-probe sonicator at 50 W, UP200Ht, Hielscher Ultrasonics, Teltow, Germany)

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Compositions comprising sugar-cysteine products US-20140348811-A1