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Data Availability Available from the corresponding author on reasonable request

For decades, the drug levodopa, commonly known as L-dopa, has been the mainstay of PD treatment

72 Chronic metformin treatment first became known as a pharmacological cause of vitamin B 12 deficiency within a decade of it coming into use and more recently decreased serum folate concentration has also been associated with its administration

Abbreviations: ALT alanine transaminase CYP the cytochrome P450 INR international normalized ratio References [1] Kur P, Kolasa-Woosiuk A, Misiakiewicz-Has K, Wiszniewska B

J Neuroimmunol 284:5766 Carlton WW (1969) Spongiform encephalopathy induced in rats and guinea pigs by cuprizone