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Research supports the critical window hypothesis HRT initiated within 10 years of menopause onset (or before age 60) provides cardiovascular protective benefits, while initiation much later may not

Neuroplasticity driven by HGF/c-Met signaling includes upregulation of brain-derived neurotrophic factor (BDNF), activation of postsynaptic density protein-95 (PSD-95), and increased expression of GluN2B-containing NMDA receptors

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