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The main benefit of topical inhalation is the delivery of relatively high doses of the drug directly to the target site, while minimizing the risk of ototoxicity and nephrotoxicity (Abramowsky and Swinehart, 1996

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It is known that the intrinsic pathway of apoptosis involves the mitochondria release of pro-apoptotic factors, such as AIF or cytochrome c, and these processes can be activated by ROS