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Conclusion The results from aforementioned studies along with fomepizoles very high safety and low adverse effect profile have led medical toxicologists to use fomepizole for treatment of selected APAP OD patients (also receiving NAC), both early and late in their courses of illnesses, but without the benefit of results from clinical trials examining effectiveness

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During the blinded data review an indication of period effect was noted and properly registered as follow up action according to the Statistical Analysis Plan of the trial protocol

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Furthermore, some carcinomas of the breast, ovary, uterus, and pancreas were shown to express GT