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Cell proliferation-promoting peptides/proteins predominantly serve on various repair cells during tissue repair by activating specific upstream pathways through binding to first the corresponding receptors and then activating two common downstream pathways such as the PI3K-Akt pathway and the Ras-Erk1/2 pathway

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Following its entry into eukaryotic cells via the transport proteins SLC1A5 or SLC7A5, tryptophan is primarily subjected to three primary metabolic pathways: incorporation into protein synthesis, metabolism via the kynurenine (Kyn) pathway, or conversion through the serotonin pathway

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A reduction in the SAM level altered the m6A modification rate and decreased the expression of PD-L1 and V-domain Ig suppressor of T-cell activation (VISTA) in cancer cells