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Moreover, the review explores the challenges and prospects of multi-target combination therapies and personalized medicine interventions in clinical practice to offer strategic guidance for the comprehensive prevention and management of DCM

[] This study identified the DNMT1HIF-1PDK axis as a chamber-specific pathway that regulates mitochondrial metabolism through DNA methylation, which drives right ventricular (RV) pathology, and established PDK inhibition as a potential therapeutic strategy to reduce fibrosis and improve RV function