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A total of 28 metabolites were found to be significant features for further analyses based on a log2 fold change cutoff of 1.5 at 10% false-discovery rate (Figure 1A

PaP: Data curation, Formal Analysis, Investigation, Validation, Writingoriginal draft

BMC.Neurol

At least 99% of AREs have now been proposed to be degenerate, with degenerate motifs associated negatively with transcriptional outcome and half sites more strongly influenced by transcription factors acting through adjacent motifs or cooperating factors [56]

However, in subsequent investigations in rodent models of depression, (2R,6R)-hydroxynorketamine did not exhibit antidepressant-like effects and increased aggressive behavior (Yang et al., 2019)