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Figure 4 The dual role of HO-1 in EP not only depends on free iron levels (including iron intake, storage, and transport) and oxidative stress, but also modulated by additional factors, including phagolysosome processing efficiency, heme transporter levels, and the functional state of macrophages (89, 91, 94)

Several types of stem cells are used, including mesenchymal stem/stromal cells (MSCs), induced pluripotent stem cells (iPSCs), fetal liver stem cells, and hematopoietic stem/progenitor cells