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Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (Datta et al., 2020

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We also confirmed the beneficial effect of short-term treatment with NOx of apple embryos isolated from aged seeds, which stimulated total antioxidant activity in the embryonic axes (Ciacka et al

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Additionally, iron overload has been shown to increase mitochondrial iron accumulation and the production of mtROS, contributing to insulin resistance in H9c2 cardiomyoblast cells [68]