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Comparison of minipig, dog, monkey and human drug metabolism and disposition

Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7

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Am J Biomed Sci Res 15(2):153177 Travagli V, Iorio EL (2003) The biological and molecular action of ozone and its derivatives: state-of-the-art, enhanced scenarios, and quality insights