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These factors ultimately contribute to degradation of articular cartilage, inflammation and fibrosis of the synovium, irritation of the nociceptors (pain), aberrant angiogenesis of the synovium, disruption of subchondral bone, and instability of ligaments and tendons

as well as chronic pathophysiological sequelae in virus-free PASC patients

First, mitochondrial dysfunction itself could result in GI dysfunction

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