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doi: 10.1139/bcb-2019-0117 189 RodriguesBGoyalRKMcNeillJH

Anderson, R., Groundwater, P

The criteria assessed were: 1

Notably, both DFO and ammonium ferric citrate enhance erastin-induced cell death, implying that although systemic iron overload exists in FRDA, cytosolic iron may still be limiting, and iron metabolism is dysregulated, contributing to cellular vulnerability

These components are considered immunological distractors with pro-inflammatory activity, capable of causing dysbiosis and increased intestinal permeability (the so-called leaky gut syndrome), so favoring the development of autoimmune diseases [142]