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2) This series of experiments completed by researchers Carvos et al systematically investigated the pharmacological effects, receptor dependence, and central mechanisms underlying cagrilintides anorectic and weight-lowering properties in mice

The SMASH score, including synovitis, cartilage destruction, and bone erosion, was analyzed according to a previous article 48

However, oxidative stress can inhibit the expression of HIF-1 and magnify inflammation, which may impair the therapeutic effect of Mg 2+ in OA (Mobasheri et al., 2017)

One example of such GPCR is the protease-activated receptor 2 (PAR2), which is specifically expressed in the plasma membrane of endometrium epithelial cells and modulates intracellular calcium levels upon activation by serine proteases like trypsin

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