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Glutathione peroxidase is an enzyme that contains 4 units of selenium as cofactors which catalyzes the breakdown of organic hydroperoxides and hydrogen peroxides

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A key future direction will be the rational design and testing of dosing regimens that explicitly account for the formation, maintenance, and exit of drug-tolerant cancer cells, which may enable more mechanistic interpretation of clinical outcomes and improve the translational relevance of intermittent or adaptive treatment strategies

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So why do we need GSH outside of the cells