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Getting a knack for NAC N-acetylcysteine, or NAC for short, is a tried-and-tested drug from the 60s that is the mainstay of therapy in acetaminophen (paracetamol) overdose

This could contribute to immune cell hyperactivation and inflammatory responses

The pathophysiology of doxorubicin and ischemia/reperfusion-induced myocardial injury in mice may be primarily associated with increased mitochondrial iron levels and lipid peroxidation, suggesting that mitochondrial oxidative damage is a principal mechanism underlying ferroptosis in this context [107]

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It also involves pro-inflammatory signaling pathways