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Mechanistically, high expression of BCAT1 reduces the NAD + /NADH ratio, increases mTORC1 activity, and promotes oxidative phosphorylation and nucleotide biosynthesis

We can use that, and are using that, as an inroad into understanding the molecular basis of that vulnerability because ultimately glaucoma is a vulnerability to pressure, and not necessarily due to pressure level per se

Endocrinology 145 , 667678 (2004)

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