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Abstract Background Chronic Obstructive Pulmonary Disease is characterised by declining lung function and a greater oxidative stress burden due to reduced activity of antioxidant enzymes such as Glutathione Peroxidase 1

& Kaatz, G

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Prodrugs In order to meet the challenges posed by the inherent unfavorable physicochemical and pharmacokinetic characteristics of PROTAC molecules, PROTAC (PRO-PROTAC) based on prodrugs has become a promising strategy in recent years (Fig