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6 Future directions and unmet needs Despite the promising nature of antioxidant therapies, several unmet needs and future directions remain critical for advancing treatment strategies

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as insulin secretion, the glycolytic and/or lipolytic potential of tissues, gluconeogenesis and likely most aspects of glucose and energy homeostasis have been found defective and implicated in the pathogenesis and/or progression of hypertension and MetS (Katsimardou et al., 2020)

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Genetic and Metabolic Determinants of Toxicity: Individual variability in drug metabolism significantly impacts the severity of toxicity