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Crushing, chewing, or dissolving these items will result in converting the extended release of hydrocodone into an immediate release and can cause an uncontrolled and rapid release of opioids, which could lead to overdose (53)

Furthermore, the biochemical relationship of Vitamin C with Glutathione helps recycle oxidised glutathione in the skin cells

The additional author of the study, An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life, was Bin Zhou of TSRI