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GLP-1 drugs primarily reduce food intake

2022 May 31;12(2):122-130

These GPCRs are activated by a wide range of endogenous ligands, including ions, lipids, nucleotides, amines, small molecules and peptides 3 , and they play crucial roles in physiological processes, such as sensory perception 4,5 , emotional regulation 6 and metabolic control 7,8

Thus, the heterozygous KEAP1 mutation conferring the growth advantage on cancers is consistent with the two-site binding model and hinge and latch model of the Keap1Nrf2 system