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In these patients the administration of these drugs may cause acute renal failure

Leptin resistance: a prediposing factor for diet-induced obesity

However, other studies suggest that cyclosporin A upregulates gingival SHH (Sonic hedgehog protein) expression in vitro, while in vivo that inhibition of the SHH pathway counteracts the stimulatory effect of cyclosporin A on gingival fibroblast proliferation