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The function of the anti-LP enzyme GPX4 can be directly inhibited, through covalent modification by compounds like RSL3 (RAS-selective lethal 3), or indirectly through GSH depletion, leading to the generation of excessive lipid peroxides, causing ferroptosis (Weaver and Skouta, 2022)

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Biochemistry 42 , 42354242 (2003)

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